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Introduction

We are the British Library Science Team; we provide access to world-leading scientific information resources, manage UK DataCite and run science events and exhibitions. This blog highlights a variety of the activities we are involved with. Follow us on Twitter: @ScienceBL. Read more

23 January 2019

Lab notebooks - handwriting at the core of science

McLaren notebook
Page from Anne McLaren's notebook (shelfmark Add MS 83844) covering embryo transfer experiments in mice, 1950s. (Copyright estate of Anne McLaren)


Today is World Handwriting Day, and we thought we’d pay our respects to the most important role handwriting plays in science, one which you might not have heard of if you aren’t a practicing scientist. This is the “lab notebook”, a scientist’s daily diary of all their experiments, thoughts, and other scientific activities. Until relatively recently, these were always handwritten, as they were meant to record what, in detail, someone was doing as they did it. Waiting to create them until work was finished caused too much risk of forgetting or distorting something.


Lab notebooks grew out of the personal diaries and notebooks of individual researchers. Some notebooks by well-known scientists have become Library treasures in their own right. One of the most famous works in our Treasures of the British Library exhibition is the Codex Arundel, a collection of notes written by Leonardo da Vinci (although probably not in the order they were bound) in the sixteenth century. At the other extreme of history, the Treasures Gallery currently displays the biologist Anne McLaren's lab book on embryo transfer in mice. Outside the BL, most of the lifelong field and theoretical notebook collections of Charles Darwin are digitised and available online, as are some of Albert Einstein's most significant theoretical notebooks. At the other end of accessibility, some of the lab notebooks of Marie and Pierre Curie, held by the National Library of France, are reported to still be so radioactive that they are not safe to handle without protective clothing.


Laboratory notebooks later became an even more important record of exactly what was done, as lone researchers were replaced by academic and private-sector research groups, science and technology became ever-more important to society, and scientists were expected to describe their methods in detail so that they could be replicated and turned into innovative technologies, materials and treatments. Additionally, until quite recently, American patent law worked on a “first to invent” basis whereby the person who could prove that they had the idea for an invention first, or their employer, had the right to a patent. Laboratory notebooks were the main source of evidence for this. In recent years, scientific misconduct has become a higher-profile issue, as scientists worry about a “replicability crisis” where too many uncertain or exaggerated results have been published. Lab books help prove that the work was done as the researchers claim, or the detail expected in them make discrepancies easier to recognise. And the notebooks of eminent scientists are a rich source for scientific historians.


By the latter part of the twentieth century, some organisations had very detailed instructions for how laboratory notebooks should be completed and stored. Lab books had to be written exactly as the work was carried out, or as soon as possible – no jotting notes on scraps of paper and writing them up at the end of the day. Notebooks were considered the property of the employer or the university, and could not be removed from the lab. And they had to be clearly paginated with no chance of pages being removed or replaced.


Many laboratories still use paper notebooks, due to the ease of simply writing notes down as you go. In many types of science, electronic devices are at risk of being exposed to spillages or damaging electromagnetic conditions, or are simply unwieldy. Some researchers also like to keep their detailed records to themselves instead of sharing them with a group. Some research groups and organisations are now moving to electronic recording, but the lifetime of electronic data can be questionable due to failure to back up and the lifespan of media. Specifically-designed electronic laboratory data systems are more secure. They are more common in industry than academia, as academics are more independent and less likely to respond to top-down orders, and academic institutions can be less able to afford the necessary software and hardware. The advantages of electronic research notes systems are that you can save large amounts of original data directly into the system without retyping or printing it, clone records from earlier experiments to save time, search your records more easily, share data within the group easily, and track the history of records. Now data is often electronically recorded and can be directly copied into a laboratory system without a transcription stage. It is possible to use general project and collaboration software packages such as Evernote, SharePoint, or GoogleDrive but specifically-designed software is now available. 


In 2011, Gregory Lang and David Botstein published a scanned copy of the entire lab notebook covering the research leading to a paper on yeast genetics, as an attachment to their e-journal article.


Modern lab books rarely find their way into the British Library collection, but our most famous example is the collection of Alexander Fleming, the discoverer of penicillin (also including records of earlier experiments by his mentor Sir Almroth Wright). As well as the material by Anne McLaren mentioned earlier, we also have some material from the photography pioneer Henry Fox Talbot, electrical inventor David Edward Hughes, and biologist Marilyn Monk.

Sources and further reading:
Barker, K, At the bench: a laboratory navigator, Cold Spring Harbor: Cold Spring Harbor Press, 2005. pp. 89-99. Shelfmark YK.2005.b.1888
Baykoucheva, S. Managing scientific information and research data, Oxford: Chandos Publishing, 2015. Available electronically in British Library reading rooms.
Bird, CL, Willoughby, C and Frey JG, "Laboratory notebooks in the digital era: the role of ELNs in record keeping for chemistry and other sciences", Chemical Society reviews, 2013, 42(20), pp. 8157-8175. Shelfmark (P) JB 00-E(105) or 3151.550000.
Elliott, CA, "Experimental data as a source for the history of science", The American archivist, 1974, 37(1), pp. 27-35. Shelfmark Ac. 1668 or 0810.390000, also available electronically in British Library reading rooms.
Holmes, FL, "Laboratory notebooks: can the daily record illuminate the broader picture", Proceedings of the American Philosophical Society, 1990, 134(4), pp.349-366. Shelfmark Ac. 1830 or 6630.500000, also available electronically in British Library reading rooms.
Stanley, JT and Lewandowski, HJ, "Lab notebooks as scientific communication: investigating development from undergraduate courses to graduate research", Physical review: physics education research, 2016, 12, 020129, freely available online at https://journals.aps.org/prper/pdf/10.1103/PhysRevPhysEducRes.12.020129.
Williams, M, Bozyczko-Coyne, D, Dorsey, B and Larsen, S, "Appendix 2: Laboratory notebooks and data storage", in Gallager, SR and Wiley, EA, Eds. Current protocols essential laboratory techniques, Hoboken: John Wiley & Sons, 2008. Shelfmark YK.2008.b.6299 or m09/.30081

18 December 2018

Arabic science manuscripts from the British Library

Kitab al sirah
The beginning of Kitāb al-sīrah al-falsafīyah, an autobiographical treatise by the physician and philosopher Abū Bakr Muḥammad ibn Zakarīyā al-Rāzī (Add MS 7473, f. 1v)


Today is World Arabic Language Day, so here's a reminder of the scientific content in our Qatar Digital Library digitisation project. Our friends on the Asian and African Studies blog created two lists of major scientific works digitised in the collection, including Arabic versions of classical scientific texts, some of which were lost from Western European culture until the Renaissance, and original works by great early scientists of the Arabic-speaking world, such as Quṭb al-Dīn al-Shīrāzī, Ibn Sīnā (Avicenna), Ibn Haytham (Alhazen), and Abū Bakr Muḥammad ibn Zakarīyā al-Rāzī (Rhazes).

27 November 2018

Cats in science

Cat image
At the end of last week, our free exhibition "Cats on the Page" opened, covering cats in all their roles in fiction and art. Here are a few examples of the roles that cats have played in science.

The most famous cat in science, of course, is the notorious Schrödinger's Cat thought experiment, put forward by the physicist Erwin Schrödinger in 1935 to express what he thought were the truly bizarre implications of the Copenhagen Interpretation of quantum physics. In this morally questionable experiment, a cat is sealed in a box with an apparatus that has a predictable probability, within a set time, of releasing cyanide gas and killing it, analogous to a subatomic particle which, until it interacts with another object, may be in one of a number of states with known probabilities. According to Schrödinger, when the probability of the cat being dead reaches 50%, it can be considered, so long as the box is not opened, to be simultaneously alive and dead. Schrödinger actually put this forward as a self-evidently ludicrous demonstation of how silly he thought that the Copenhagen interpretation was, but many physicists since have taken it entirely seriously, and single atoms or subatomic particles have been demonstrated in real-world experiments to behave as if they are in two states simultaneously.

There has been at least one recorded case of a cat being credited writer on a peer-reviewed scientific paper. In 1975, the physicist and mathematician Jack H Hethrington was irritated when a peer reviewer for Physical Review Letters pointed out that he had used "we" consistently in a manuscript on which he was the only credited author, and that the journal style guide would require this to be corrected to "I" throughout. Rather than rewrite the paper, Hethrington credited his cat, Chester, as the second author "F D C Willard", the "FD" coming from Felis domesticus and Willard from the name of Chester's father. In 1980 he published a popular science article under the name of Willard alone. In this case, it was reportedly motivated by disagreements between him and some co-authors, leading to them not wanting to credit it to any real person.

That example was not motivated by hostility, but stings based on exposing questionable degrees or dubious professional organisations by having animals "earn" qualifications have a long history. The first case seems to have taken place in 1967 when a Television Wales team investigating a bogus "English Association of Estate Agents and Valuers" successfully got them to appoint a cat named "Oliver Greenhalgh" as a fellow. British science writer Ben Goldacre has exposed the dubious nature of certain "nutritionist" qualifications by getting his cat a professional certification. To rub salt in, the cat had been dead for some time.

And finally, cats may some day have a role in protecting post-apocalyptic humans from our darker legacies if our technological civilisation collapses. A serious proposal has been made to genetically engineer cats to change colour or glow if they encounter radioactivity, and create a legend that they can detect evil, in order to prevent far-future peoples from unknowingly digging up still-hazardous nuclear waste dumps.

Posted by Philip Eagle (Subject Librarian - STM)